|
Solirna Biosciences Ltd, a subsidiary of Genesis, is developing technology to deliver separate complementary strands of RNA and let them anneal inside the cell where they can induce gene specific RNAi, thus combining the best aspects of antisense and siRNA technologies.
The novel gene silencing technology being developed by Solirna has the potential to solve the siRNA delivery problem by combining the delivery advantages of antisense oligonucleotides with the potent mRNA knockdown of siRNA, to yield a novel and vehicle-free gene silencing technology. The oligonucleotide will be delivered without a vehicle as chemically-modified, nucleobase-masked, single-stranded RNAs, which will form an active double-stranded molecule only when the masking groups are removed inside cells. Intellectual Property Multiple US provisional patent applications have been filed covering the design, modification and delivery of single-stranded oligonucleotides which anneal intra-cellularly and then initiate RNAi.
|